What’s the cost of a flight from Panama City to Santo Domingo La Isabela?

Prices vary based on date, airline, and availability. Compare several options if you're flying between Panama City and Santo Domingo.

Choose a date to explore the best fares now.

If possible, avoid holiday periods: ticket prices tend to rise quickly and availability drops, especially on busy routes. Morning and evening flights are often in high demand too — book early to get a good fare.

Which airports serve Panama City and Santo Domingo?

When planning a trip of about 909 mi, it's a good idea to check flights from surrounding airports too.

• Airports in Panama City: Panama City is connected to 2 airports - Pacífico International Airport, Paitilla.
• Airports in Santo Domingo: The only active airport in Santo Domingo is Santo Domingo - La Isabela.

The closest airport isn’t always the cheapest — it’s worth checking the alternatives too. In some cities, smaller airports offer lower fares than the main ones.

Find flights from Panama City to Santo Domingo La Isabela that suit your schedule

Use Jetcost to sort and filter results based on your preferred flight time, number of stops, price range, or airline. View deals from Delta, United, American, and booking sites like Expedia and eDreams.

Other popular destinations

Interested in Dominican Republic? These cities are also in demand: La Romana, Puerto Plata, Punta Cana, Santiago, Santo Domingo.

Connecting flights can be cheaper but often mean longer layovers. You can easily select either direct or connecting flights with a single click using the filters.