How much is a flight from Panama City to Santo Domingo?

Prices vary based on date, airline, and availability. Compare several options if you're flying between Panama City and Santo Domingo.

$277 is the lowest fare found in the past 15 days.

Fares change often — checking several times throughout the week can make a big difference. Booking in advance often means access to lower prices for the Panama City - Santo Domingo route.

Planning flights between Panama City and Santo Domingo? Don’t forget the airport options

Especially when flying to medium or large cities, it's worth checking all possible airport combinations before booking.

• Airports in Panama City: 2 airports are listed in Panama City - Pacífico International Airport, Paitilla.
• Airports in Santo Domingo: Other arrival options include La Isabela.

Check for differences in transport costs to and from each airport — they affect your total spend. Choosing the right airport can make a real difference in price and timing.

Find the best flight from Panama City to Santo Domingo

With Jetcost, you can filter results by flight time, airline, price range, and layovers. Choose direct or connecting flights, round-trip or one-way, and compare offers from Delta, American, United, and more.

Other popular destinations

Searching for flights to Dominican Republic? Travelers also looked at: Puerto Plata, Punta Cana, Samaná, Santiago, Santo Domingo.

Use filters to exclude options that don’t match your budget or travel preferences and personalize your search for Panama City – Santo Domingo flights.