What’s the cost of a flight from Knoxville to Des Moines?

Prices vary based on date, airline, and availability. Compare several options if you're flying between Knoxville and Des Moines.

The lowest fare seen in the past 15 days was $339.

If possible, avoid holiday periods: ticket prices tend to rise quickly and availability drops, especially on busy routes. Morning and evening flights are often in high demand too — book early to get a good fare.

Is there more than one airport in Knoxville or Des Moines?

Even short-haul routes can benefit from considering secondary airports. It may open up more flight times or cheaper fares.

• Airports in Knoxville: Only Knoxville - McGhee Tyson is currently operational.
• Airports in Des Moines: Des Moines is the only airport in operation.

Airports with more daily flights offer more flexibility if plans change or delays occur. If you’re flexible, consider airports near Des Moines as well.

Plan your journey from Knoxville to Des Moines with ease

Use Jetcost to tailor your search — direct or connecting flights, round-trip or one-way, filtered by airline, price, travel time, or agency.

Other popular destinations

Exploring options in United States? These cities are trending: Atlanta, Los Angeles, Miami, New York City, Orlando.

Flight availability can change quickly — refresh the results if you’ve been away from the page for a while.