How much is a ticket from Chicago Midway to Des Moines?

Depending on when you travel and how far in advance you book, fares between Chicago and Des Moines can differ a lot.

The lowest fare seen in the past 15 days was $42.

If you’re flexible with timing, consider overnight flights — they often cost less and are less crowded. Exploring multiple date and time combinations can help you find the cheapest solution.

Which airports serve Chicago and Des Moines?

When planning a trip of about 305 mi, it's a good idea to check flights from surrounding airports too.

• Airports in Chicago: Chicago is connected to 3 airports - Midway, O'Hare, Rockford.
• Airports in Des Moines: The only active airport in Des Moines is Des Moines.

The closest airport isn’t always the cheapest — it’s worth checking the alternatives too. In some cities, smaller airports offer lower fares than the main ones.

Smart ways to search flights from Chicago Midway to Des Moines

Use Jetcost to view tailored results based on what you care about — time, duration, number of stops, or even your preferred booking agency. Results include carriers like American, Delta, United, and more.

Other popular destinations

Flying to United States? Other travelers also searched: Atlanta, Los Angeles, Miami, New York City, Orlando.

Prefer non-stop flights? Just activate the filter to skip unnecessary layovers. If your dates are flexible, you can also explore different departure and return combinations to find the best fit.