What’s the cost of a flight from Mexico City to Santa Cruz de la Sierra?

Prices vary based on date, airline, and availability. Compare several options if you're flying between Mexico City and Santa Cruz.

The lowest fare seen in the past 15 days was $816.

If possible, avoid holiday periods: ticket prices tend to rise quickly and availability drops, especially on busy routes. Morning and evening flights are often in high demand too — book early to get a good fare.

Planning flights between Mexico City and Santa Cruz? Don’t forget the airport options

Especially when flying to medium or large cities, it's worth checking all possible airport combinations before booking.

• Airports in Mexico City: Another departure airport is International.
• Airports in Santa Cruz: Other arrival options include Santa Cruz.

Check for differences in transport costs to and from each airport — they affect your total spend. Choosing the right airport can make a real difference in price and timing.

Plan your journey from Mexico City to Santa Cruz de la Sierra with ease

Use Jetcost to tailor your search — direct or connecting flights, round-trip or one-way, filtered by airline, price, travel time, or agency.

Other popular destinations

Exploring options in Bolivia? These cities are trending: Cochabamba, La Paz, Santa Cruz, Sucre, Tarija.

Flight availability can change quickly — refresh the results if you’ve been away from the page for a while.